COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms

Secretion from Mast Cells: Mechanisms of Neutrophil Defensins Induce Histamine

Histamine, Mast Cells, and Heart Failure

e have known about histamine receptors in the heart for any years (1). The human H1and H2-histamine recepors were cloned and characterized in the early 1990s (2,3), ollowed closely by the human H3and H4-histamine eceptors several years later (4,5). Histamine is a natural ody constituent that is found throughout the body, espeially the central nervous system, mast cells, gastric mucosa arietal c...

Mast Cells as Sources of Tissue Histamine

Enumeration of mast cells and determination of histamine in sections of dog skin and dog lung have shown that the regions of the tissue rich in mast cells are also rich in histamine. In the skin, the outer layers of the dermis contain higher concentrations of histamine and mast cells than any other region. Average values of the histamine content and mast cell count for dog liver, heart, muscle,...

Mechanisms of nonimmunological histamine and tryptase release from human cutaneous mast cells.

BACKGROUND If mast cells are stimulated they release multiple mediators that delineate markers for immunologic and nonimmunologic reactions; histamine and tryptase are the two best known. Although histamine can be assayed in plasma, it is a nonspecific marker with a very short half-life. Tryptase has a longer half-life, but its release has not been proven to be specific for anaphylaxis. The aut...

Relation of mastocytoma to mast cell leukemia, and of heparin, histamine and serotonin to mast cells.

LTHOUGH mtich information about mast cells has become available in recent years ( reviews by Padawer,’ Uvn#{228}s,2Riley1 ) , little is known about the function of these cells. The relation of tissue mast cells to blood basophil leukocytes has been debated since their discovery. Because of their similar staining properties, Ehrlich4 regarded the latter as blood mast cells. The availability of a...